Simplicef is a kind of broad-spectrum antibiotic that provides ample antimicrobial action against most members of the Gram negative and Gram positive species of bacteria except Pseudomonas aeruginosa, Bacteroides fragilis, and Enterococcus species. It contains Cefpodoxime, a 3rd generation of antibiotic that belongs to the class of antimicrobials known as cephalosphorins. This antibiotic is approved by the FDA for the exclusive use in dogs that are diagnosed with infections of the respiratory tract, the skin, ears, and the urinary tract. It is available in tablet formulations for once a day dosing for 5 to 7 days or as deemed appropriate by a veterinarian. However, it should never be administered for more than 28 days and should never be given to cats.

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Simplicef (Cefpodoxime proxetil) is a broad spectrum antibiotic that is primarily indicated for the management of the following infections in dogs.

  • Skin infections

The canine skin, like that of humans, is actually host to a variety of microorganisms. They reside on the surface of the skin and are considered to be generally harmless as long as the dog’s immune system is functioning properly. Unfortunately, cuts, scrapes, abrasions, or any other condition that undermines the integrity of the canine skin can result in the entry of microorganisms into the deeper structures of the skin, producing an infection.

The most common culprits in dog skin infections include Staphylococcus species, group B Beta-hemolytic Streptococcus canis, Proteus mirabilis, Pasteurella multocida, and Escherichia coli. Good thing, these bacterial species are effectively managed by Cefpodoxime. 

  • Respiratory tract infections 

Pneumonia and bronchitis are often found in dogs that have lowered immune responses. The primary defense mechanisms are often not functioning well, allowing the entry of microorganisms in an area of the dog’s body that should be considered sterile or free of any microorganism. The entry of microorganisms initiates a series of inflammatory processes leading to a full blown respiratory tract infection.

Bordetella bronchiseptica, Pasteurella multocida, Pseudomonas aeruginosa, Klebsiella pneumonia, Streptococcus zooepidemicus, Mycoplasma species, and Escherichia coli are often the causative organisms of respiratory tract infections in dogs. With the exception of P. aeruginosa, Cefpodoxime can easily control and kill these microorganisms. 

  • Urinary tract infections 

Dogs that are not drinking enough water are more predisposed to urinary tract infections because microorganisms are not effectively flushed out of the system, allowing them time to proliferate. Some of the more common microorganisms that cause UTI in dogs include Escherichia coli and Staphylococcus, Proteus, Klebsiella, Streptoccocus, and Enterobacter species. 

  • Ear infections 

That incessant scratching of your dog’s ears can mean a lot of things. But if you also happen to smell a distinct odor or even secretion, then that is already an ear infection you’re talking about.

Canine ear infections are often brought about by Corynebacterium, Streptococci, Proteus, and Escherichia species. Simplicef (Cefpodoxime proxetil) can also manage these infections.

Benefits of Simplicef

Being a broad-spectrum cephalosphorin, Simplicef can bring a host of benefits for you and your dog. Here are some of them.

  • Faster resolution of infections 

Cephalosphorins are somewhat similar to penicillins in their mechanism of action and are thus, considered to be one of those types of antibacterial preparations that are used as primary antibiotics. Cefpodoxime has the added benefit of being able to address both Gram negative and positive organisms that earlier cephalosphorins could not. This allows Simplicef to combat a wider range of bacteria to bring about faster resolution of the infection.

  • More convenient dosing and administration 

Because of its powerful action, you don’t need to administer Simplicef every n number of hours. It has a long plasma half-life that allows it to be given to your dog on a once-a-day dosing. The plasma half-life of a drug is generally described as the length of time that the amount of the active ingredient of the drug is reduced in half.

For example, if the plasma half-life of a 100 mg tablet is 12 hours, then you know that 12 hours after giving the drug, there will still be 50 milligrams of its active ingredient left in the body. Give it another 12 hours and the drug will be reduced further in half to 25 milligrams, and so on. What this means is that you can administer Simplicef once a day and will still feel confident that its active ingredient, Cefpodoxime, will still be present in minimal amounts on your next dosing schedule.

  • Improved comfort for your pooch

Being down with an infection is sure to make your pooch feel so low. It won’t be able to eat well. It won’t be able to really rest well, either. More importantly, it will not be able to enjoy the things that it usually does. Thankfully, by giving Simplicef, you can minimize the severity of the symptoms and allow your pet to feel a lot more comfortable.

How Simplicef Works

The mechanism of action of Simplicef (Cefpodoxime) is similar to other cephalosphorins except that its antibacterial spectrum occurs on a much broader scale. Cefpodoxime kills susceptible bacteria by preventing the bacteria from creating cell wall. More specifically, it prevents the final inclusion of a variety of peptides into peptidoglycan molecules. No peptidoglycan, no bacterial cell wall. This leaves the core of the bacteria especially vulnerable to immune system cells. Additionally, exposing the insides of the bacteria to extracellular fluid severely disrupts many bacterial chemical processes leading to their demise.

One of the most important characteristics of Cefpodoxime is that it has an excellent absorption rate. Whereas other antibiotics can only manage 30 to 40 percent absorption rate, Cefpodoxime boasts of a 50% absorption rate, making it ideal for once daily dosing.

healthy dog

Potential Side Effects

Like all antibiotics, Simplicef comes with a few side effects, too. These typically include the following:

  • Nausea and / or vomiting
  • Diarrhea
  • The presence of blood or mucus in the stool
  • Unexplained bruising or bleeding

While these can be considered generally benign, do understand that some dogs may be hypersensitive to Cefpodoxime. In such cases, you will have to stop the administration of Simplicef and bring your pooch immediately to the vet or to an emergency vet clinic nearest you. An allergic reaction typically manifests through the following signs and symptoms.

  • Shortness of breath or difficulty breathing
  • Fainting
  • Unexplained rashes or hives
  • Swelling of the dog’s face, tongue, and /or lips

Things You Should Know about Simplicef

Simplicef is a broad spectrum antibiotic that is primarily intended for use on dogs that have skin, wounds, and soft tissue infections as well as infections of the respiratory tract, the ears, and the urinary tract. It is duly approved by the FDA and is available in 100- and 200- milligram tablet formulations. It is best administered with food to allow for better absorption. The therapy should last a minimum of 5 to 7 days but should not exceed more than 28 days. Typically, therapy is continued for an additional 2 to 3 days after the last day of observable symptoms.

What You Should Tell Your Vet Before He Prescribes Simplicef

Because Cefpodoxime is almost similar to penicillin, it is important to inform your veterinarian if your dog has allergies to penicillin or to any other cephalosphorin. If your dog has a kidney problem or even a gastrointestinal condition, your vet may have to either adjust the dosage or even change the antibiotic altogether. It is also important to inform your veterinarian if your pooch is lactating or pregnant. While this type of antibiotic is considered safe, it still a lot better to be cautious.

How to Give Simplicef to Your Mutt

The recommended dose of Simplicef is 2.3 milligrams to 4.5 milligrams for every pound of your pooch’s body weight to be given on a daily basis. It is critical to measure the correct weight of your pooch so that you will be able to administer the correct dose. As already explained, you need to administer Simplicef with food and for about 5 to 7 days or even longer but not exceeding 28 days. You are also required to continue giving Simplicef for an additional 3 days from the day you last noticed any clinical manifestation of an infection.

What to Do If You Miss a Dose

In case you missed giving a dose to your dog, there’s no need to fret. You can immediately give the dose to it, provided it’s not yet close to its next dose. If so, then simply disregard the missed dose. What you should never ever do is to double the next dose as this can be harmful to your pooch.

What to Do in Case of Simplicef Overdose

As we have already mentioned above, if your pooch presents itself with any sign of an allergic reaction or any of the following signs that may indicate Simplicef toxicity, then you need a vet immediately.

  • Abdominal cramps
  • Severe nausea and vomiting
  • Very loose, watery stools

dog sitting on a couch

Some Drug Interactions

There are certain canine drugs that may adversely affect the therapeutic effectiveness of Simplicef. These can include other antibiotics, furosemide, probenecid, and warfarin.  OTC drugs, herbal supplements, and nutrient supplements may also have an impact on Simplicef.

Simplicef (Cefpodoxime) is a broad-spectrum antibiotic that is excellent in fighting infections of the skin, respiratory tract, urinary tract, and ears of dogs. It is safe and comes in a very convenient once-daily dosing.

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Olivia Williams
Olivia is our head of content for, mum of one and a true animal lover. With 12 different types of animal in her family, it's never a dull moment. When she isn't walking the dogs, feeding the cats or playing with her pet Parrot Charlie, you will find her product researching and keeping the site freshly updated with the latest products for your pets!


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