K9 Advantix Flea Control for Dogs

K9 Advantix II Flea Control Review

Pet parents are always wary about fleas infesting their beloved dogs. Unfortunately, fleas are not the only nemesis of man’s best friend. There are also ticks and lice to think about. Mosquitoes and biting flies can also bring a variety of illnesses to our beloved hounds. You can always choose to buy treatments for each of these pests, but this will easily set you back for a few hundred dollars. Moreover, there simply is no way of telling if the products you’re going to use will not interact with each other. As such, you’ll need a product that not only addresses the perennial problem of fleas, but also gives you peace of mind in controlling other pests. The K9 Advantix II treatment fits the bill perfectly.

K9 Advantix II is a multi-action preventative that not only kills and repels fleas, it also repels and kills lice, biting flies, mosquitoes, and 4 species of ticks. Formulated by one of the world’s leading manufacturers of veterinary products, Bayer, K9 Advantix II provides ample protection for your pet against these pests in a simple, easy-to-apply topical solution.

K9 Advantix II is available in 4 different strengths intended primarily for small dogs between 4 to 10 pounds, medium-sized dogs between 11 and 20 pounds, large-sized dogs between 21 and 55 pounds, and extra-large dogs weighing over 55 pounds. Regardless of the variant, you will essentially get all 3 active ingredients that have been proven in the management of fleas, ticks, lice, mosquitoes, and flies. This helps make sure that your dog is adequately protected.

The waterproof formulation of K9 Advantix II is especially useful since other products require a 3-day wait period before the dog can be bathed after the administration of the topical flea treatment. Moreover, most products only address fleas or fleas and ticks, but not include lice and mosquitoes let alone biting flies. For best results, however, Bayer recommends using non-detergent shampoos when bathing dogs after K9 Advantix II treatment.

K9 Advantix II is especially formulated to kill and repel ticks. These include the following species.

  • Deer ticks that cause anaplamosis and Lyme disease
  • American dog ticks that cause ehrlichiosis, tularemia, and Rocky Mountain spotted fever
  • Brown dog ticks that cause Rocky Mountain spotted fever, bartonellosis, ehrlichiosis, babesiosis, anaplasmosis, and canine hemoplasmosis
  • Lone Star ticks that cause tularemia and ehrlichiosis

The formulation of K9 Advantix II also helps kill and repel mosquitoes that carry the causative agent of heartworm disease in dogs, Dirofilaria immitis. While K9 Advantix II does not kill the heartworm itself, being able to kill and prevent the mosquitoes that carry the parasite is enough for protecting your pet against this potentially life-threatening disease. Heartworm disease primarily affects the large blood vessels of the heart which can extend well into the heart itself. This greatly reduces the ability of the heart to deliver blood to the rest of the dog’s body. If you can help prevent mosquitoes from transmitting Dirofilaria immitis, then you’re actually saving your hound.

One of the most appealing characteristics of K9 Advantix II is that you don’t need to wait that long before it starts killing fleas and other pests. Its formulation allows it to start killing fleas on your dog within the first 12 hours after application. This lasts for a full 30 days. Reinfesting fleas are also effectively killed in as little as 2 hours. More importantly, however, is the fact that K9 Advantix II is effective not only on adult fleas and eggs, but also larvae and the more resilient pupae. This means you get rid of the entire population of fleas on your dog from eggs all the way to adults.

The other good news, as we have already stated, is the fact that K9 Advantix II is also effective against lice and even biting flies. While these pests may not be as popular as fleas and ticks, they do pose substantial threat to our canine friends. The formulation is especially effective against chewing lice that can introduce bacteria, parasites, or even tapeworms into your dog. These organisms can also lead to anemia which can weaken your hound. Being able to kill and repel lice is definitely a good thing to have.

Biting flies such as horse, deer, and stable flies are known ‘blood-suckers’. K9 Advantix II is currently the only topical preparation that is known to be effective against these insects, protecting your pet in the process. These may only produce local irritation, but some dogs have been reported to develop systemic reactions to the different proteins present in the saliva of these biting flies.

You may also like our review of the Best Flea Treatments for Dogs.
Key Features:
  • Multi-action formulation that kills and controls 5 types of canine pests: fleas, ticks, lice, mosquitoes, and biting flies
  • Easy-to-apply, spot-on waterproof formulation
  • Once-monthly dosing
  • Contains 3 active ingredients in one formulation
  • Kills pests on contact; requires no biting


  • Imidacloprid
  • Permethrin
  • Pyriproxifen

How Does This Product Work?

The mechanism of action of K9 Advantix II is inherent in the action of its 3 principal ingredients imidacloprid, permethrin, and pyriproxifen.

Imidacloprid is classified as a broad-spectrum, systemic insecticide. It exerts its insect-killing action by acting on the central nervous system of susceptible pests. More specifically, imidacloprid blocks nicotinic acetylcholine receptors. Acetylcholine is a major neurotransmitter that facilitates communication between and among adjacent neurons. When acetylcholine is blocked, nerve impulses don’t get transmitted. This leads to paralysis and the eventual death of the insect.

Imidacloprid doesn’t need to be ingested by the insect to exert its effects. This is what gives the K9 Advantix II its no-biting requirement. However, it also exerts its full insecticidal properties when fully ingested so that it can continue protecting your pet for a whole 30 days. Although Imidacloprid has been around for more than 30 years, it remains one of the most popular and most effective treatments against fleas.

Permethrin, on the other hand, is primarily involved in the management of lice as well as scabies mites. It is also effective in the control of mosquito-borne diseases such as malaria and dengue fever, although our primary concern among dogs is the transmission of Dirofilaria immitis, the causative agent of heartworm disease in dogs. While permethrin doesn’t kill Dirofilaria immitis, its ability to repel mosquitoes that may harbor the parasite should give pet parents the peace of mind they need protecting their pets.

Permethrin belongs to the class of insecticides known as pyrethroids and as such its mechanism of action is similar to all members of the group. Permethrin is an axonic excitoxin. What it does is that it keeps sodium channels open in the cell membrane. This prevents the repolarization or the return of the cell membrane to its resting state. This makes the cell membrane of the axons of the insects to be completely depolarized, leading to paralysis and death.

Pyriproxifen, the 3rd ingredient of K9 Advantix II, is an insect growth regulator that is highly effective against a variety of arthropods. What it does is that it prevents arthropod larvae from ever reaching their full maturity, robbing them of the ability to reproduce. While pyriproxifen may not kill susceptible organisms outright, its ability to disrupt the normal life cycle of insects can ensure that future infestations are prevented. Its ability to change the anatomy of the juvenile insect also leaves these organisms more vulnerable to other treatments as well as the dog’s own immune system cells.

Pyriproxifen is also believed to act on insect eggs by inducing sterility or even disrupting normal insect behavior. The egg may still hatch into larvae but their pathogenicity will be substantially weakened that they no longer pose a threat to the host.

It is this triad of proven insecticides that gives the K9 Advantix II its definite advantage over other preparations. It is also this unique combination of ingredients that gives K9 Advantix II a wide range of insecticidal activity.

K9 Advantix II offers pet parents an all-in-one solution to their doggie problems related to fleas, ticks, lice, mosquitoes, and biting flies. It is very easy to use and offers a full 30-day protection for your pet. It is definitely worth having on your canine friend than going on single-ingredient, single-purpose treatments.



  1. Imidacloprid – National Pesticide Information Center
  2. K9 Advantix II – 1800 Pet Meds
  3. K9 Advantix II – Bayer DVM

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