Deramaxx is a non-steroidal anti-inflammatory drug or NSAID that contains the active ingredient Deracoxib. It is primarily used in the control and management of moderate to severe pain as well as inflammation that typically occurs as a result of tissue injury such as after surgery and even osteoarthritis in dogs. Deramaxx should not be confused with Celebrex or celecoxib as the latter is primarily intended for pain and inflammation management in humans.
Deramaxx is a special formulation of a type of NSAIDs known as cyclooxygenase-2 (COX-2) inhibitors. These substances prevent the conversion of arachidonic acid into prostaglandins, thromboxane A2, and prostacyclin, 3 molecules that are largely considered in the scientific community as pro-inflammatory. Thromboxane A2 is involved in platelet aggregation that forms blood clots around injured tissues which can add to the overall inflammatory effect. Prostacyclin, on the other hand, increases the diameter of the blood vessels while also inhibiting the activation of platelets. Prostaglandin, for which Deracoxib principally affects, has actions that are similar to Prostacyclin but with the addition of producing inflammation, for which it has no equal.
Since Deracoxib is a COX-2 inhibitor, you can expect its effects to be a negation of the physiologic processes attributed to the 3 products of arachidonic acid conversion.
The analgesic and anti-inflammatory properties of Deramaxx make it exceptional in the management of pain and inflammation in the following health conditions and situations.
- Canine osteoarthritis
Osteoarthritis is also known as degenerative arthritis and is a very common occurrence among senior dogs because of a loss of integrity in the cartilage tissues that cover the ends of bones near the joints. Normally, the cartilage provides a protective cushion that works exceptionally well with the synovial membrane and synovial fluid in reducing friction forces produced by the movement of the two opposing bones. This allows the bones to glide opposite each other without causing pain or swelling. Unfortunately, over time, the integrity of the cartilage is lost, thus exposing the surfaces of dense bone where nerve endings are found. The resulting cartilage tissue damage stimulates the synthesis of prostaglandins and other pro inflammatory substances. This leads to pain and inflammation. Deramaxx helps control the pain and inflammation in osteoarthritis by affecting the way prostaglandins are synthesized.
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- Post-orthopedic surgery
In similar manner, surgical procedures performed on the bones or even on teeth, can be considered as leading to tissue injuries. That said, prostaglandins are again synthesized as an automatic response by the dog’s body to control the injury. This produces inflammation and pain. Again, Deramaxx helps by making sure prostaglandins are not synthesized to the point that they cause inflammation and pain.
Benefits of Deramaxx
You can look at Deramaxx like any other pain reliever. But one thing that separates it from others is that it is the only brand that is duly recognized and approved by the FDA for use on dogs that are experiencing pain and inflammatory syndromes. Of course, it has many benefits related to its analgesic and anti-inflammatory properties such as the following.
- Promotes comfort
If you have a dog that is in tremendous pain, you know that it won’t be eating well or even have adequate rest and sleep. In many ways it will be quite irritable and frustrated because every movement it makes is going to be painful. For your dog, although it may not be able to verbalize it, being in pain is simply an uncomfortable experience. Even if they want to play with you, they will be thinking of the pain. They would like to eat but moving their limbs can be quite painful already. By alleviating their pain and inflammation, you are essentially improving their comfort levels, allowing them to eat, play, drink, cuddle up, and do many of the things that they love doing.
- Improves overall mobility
Akin to promoting comfort is the improvement in your dog’s mobility. Dogs are inherently social creatures. They love to be around their masters and his family as well as around other people and around other dogs and pets. But how can they achieve this if they are confined to a certain area of the house because they simply cannot move? Giving them a powerful analgesic and anti-inflammatory like Deramaxx can help improve their mobility. They can run, jump, walk, and even swim without having to suffer the pain of movement.
- Facilitates faster recovery
While inflammation can be considered as the body’s natural response to tissue injury, there are other means upon which the injury can be healed. Pain can make your dog not want to eat which deprives it of essential nutrients necessary for its healing and recovery. Pain will also prevent your dog from reaching its bowl of water so it might end up thirstier and more dehydrated, again leading to prolonged healing time. By alleviating pain and inflammation, you are essentially removing another burden from your dog’s system. This allows it to find the strength to help itself recover.
- Promotes overall wellbeing for your dog
We did mention above that pain can literally suck the life out of your pooch. You’d see it depressed and bored. It wants to jump and run but cannot do so because of the pain. It wants to greet you at the door when you come home from work yet s unable to do so, again because of the pain. Addressing the inflammation and pain can help minimize behavioral and social issues that might arise if your pooch continues to be confined in just one area of your home. It won’t get exercise which is critical to muscle toning and cardiovascular functioning. It’s like this. Do you feel happy if you are in pain? If your answer is ‘no’, now try transferring this feeling to your dog and you’d understand why you really have to alleviate the pain it is going through.
How Deramaxx Works
Deracoxib is an NSAID that acts specifically on the cyclooxygenase-2 enzyme which has been shown to be the principal mediator of inflammatory processes. Deracoxib specifically prevents the conversion of arachidonic acid into 6-keto PGF1 and PGE1, variants of prostaglandins. When given in the right dose, usually around 2 to 4 milligrams per kilogram of your dog’s weight per day, Deracoxib does not have an effect on COX-1 which is known for facilitating the typical physiologic processes associated with prostaglandins.
Potential Side Effects
While Deramaxx is especially formulated and thus, considered safe for dogs, it doesn’t necessarily mean that it doesn’t have any side effects. Because it is administered via the oral route, you can expect the side effects to be confined to the digestive tract such as the following.
- Abdominal pain
- Abdominal tenderness
- Decreased appetite
However, because the action of Deramaxx is related to the inhibition of the physiologic action of prostaglandin and other related pro-inflammatory compounds, it is also possible to observe adverse reactions.
- Black and tarry stools or bright red stools
- Bloody vomit
- Skin rashes
- Severe itching
- Unexplained and unusual weight loss
- Changes in urination
- Unexplained lethargy or fatigue
- Unusual bleeding or bruising
- Yellowing of the eyes
- Unexplained change in your dog’s behavior
If any of these manifestations are present, you should discontinue Deramaxx immediately and bring your mutt to your veterinarian. Chances are your dog is already experiencing very severe adverse reactions. You should seek veterinary consultation, too, if your pet suddenly develops any of the following signs of severe allergic reaction.
- Labored breathing
- Swelling of the face, lips, or tongue
Things You Should Know about Deramaxx
Deramaxx is fully approved by the FDA for use on dogs. It is available in 4 different formulations of scored, chewable tablets with tasty beef flavor for easier administration. These include 25 mg, 50 mg, 75 mg, and 100 mg formulations. The usual recommended dose of Deramaxx is 0.45 to 0.91 milligrams per pound of body weight per day for pain associated with osteoarthritis. The computed dose is given once a day or as your veterinarian deems fit. If Deramaxx is to be intended for long term use, your veterinarian will recommend the lowest possible dose that can still exert its therapeutic effects.
Since Deramaxx alters the function of prostaglandins, prostacyclins, and thromboxanes, serial blood tests may be required before the administration of the analgesic and anti-inflammatory. Blood tests will also be required in periodic intervals especially if Deracoxib is being entertained for long term control of pain and inflammation.
Do understand that Deracoxib can only be obtained with a prescription from your veterinarian. The tablets should always be stored in a cool dry place, preferably at room temperature within the range of 59oF and 86oF.
What You Should Tell Your Vet before He Prescribes Deramaxx
Always inform your veterinarian if your dog is already taking other pain relievers like Rimadyl, Etogesic, Metacam, Previcox, or even Aspirin. It is also important to tell your vet if your pet is allergic or is hypersensitive to the active ingredient of Deramaxx, Deracoxib. Other conditions that may require adjustment in the Deramaxx dosing or not given altogether include high blood pressure, stomach ulcers, liver disease, bleeding in the digestive tract especially the stomach, kidney disease, bleeding disorders, and problems in the cardiovascular system. Pregnant and / or lactating dogs are also not recommended to receive Deramaxx. It is equally important to let your vet know if your mutt is receiving steroid medications such as prednisolone, methylprednisolone, and prednisone.
How to Give Deramaxx to Your Mutt
Depending on the purpose of the Deracoxib therapy, you are expected to administer the following dosing recommendations.
- For post-operative inflammation and pain – 1.4 to 1.8 milligrams per pound to be given once every day for no more than 7 days. Additionally, this should only be given to dogs that weigh at least 4 pounds.
- For pain and inflammation secondary to osteoarthritis – 0.45 to 0.91 milligrams per pound given once a day.
Giving Deramaxx should be easy as it comes in chewable beef flavored tablets. It can also be given with meals or without, although we would personally recommend giving it with food to help minimize gastric reactions. Keep in mind that Deramaxx is only for dogs. Under no circumstances are you supposed to give it to your pet cat or even to someone in your family who may have a need for pain relievers. As such, make sure to secure these properly.
What to Do If You Miss a Dose
Like all canine medications, missing a dose simply requires skipping the dose altogether especially if it the next scheduled dose is almost near. However, if there is still considerable time before the next scheduled dose, then you should give the missed dose at once. Don’t ever make the mistake of doubling the dose to compensate for the missed dosing.
What to Do in Case of Deramaxx Overdose
You should bring your dog to your veterinarian or the veterinary emergency clinic if you observe any of the following signs and symptoms as these may already indicate Deracoxib overdose or toxicity.
- Dark tarry stool
- Bloody diarrhea
- Increased frequency and volume of urination
- Increased thirst
- Lethargy or unexplained weakness
- Pale gums
- Heavy or labored breathing
- Behavioral changes
Some Drug Interactions
Deracoxib should never be given to a dog that is also receiving other types of NSAIDs. It is also not ideal to give Deracoxib if your pooch is taking Triamcinolone, Prednisolone, Dexamethasone, Cortisone, or any other corticosteroid. Other medications that can affect Deracoxib include probenecid, cough medications, antihistamines, furosemide, and warfarin. Your best recourse is to have a discussion with your veterinarian and list down all the different substances – medications and supplements – that your pooch is currently taking. Your vet can tell you which ones you can keep for your dog and which ones you should simply avoid.
Deramaxx promises exceptional relief of moderate to severe pain associated with osteoarthritis and post-surgical procedures in dogs. It also reduces the various processes associated with inflammation by inhibiting the conversion of arachidonic acid into prostaglandin as well as other proinflammatory substances. Unfortunately, because these substances play a role in different processes, too, side effects and adverse reactions may limit the effectiveness of Deracoxib.
- Deracoxib (Deramaxx) – PetMD